2017

Andersen MN, Ludvigsen M, Abildgaard N, Petruskevicius I, Hjortebjerg R, Bjerre M, Honoré B, Møller HJ, Andersen NF. Serum galectin-1 in patients with multiple myeloma: associations with survival, angiogenesis, and biomarkers of macrophage activation. Onco Targets Ther. 2017 Apr 4;10:1977-1982. doi: 10.2147/OTT.S124321. eCollection 2017. PubMed PMID: 28435287; PubMed Central PMCID: PMC5388249.
 

Casneuf T, Xu XS, Adams HC 3rd, Axel AE, Chiu C, Khan I, Ahmadi T, Yan X, Lonial S, Plesner T, Lokhorst HM, van de Donk NWCJ, Clemens PL, Sasser AK. Effects of daratumumab on natural killer cells and impact on clinical outcomes in relapsed or refractory multiple myeloma. Blood Adv. 2017 Oct 24;1(23):2105-2114. doi: 10.1182/bloodadvances.2017006866. eCollection 2017 Oct 24. PubMed PMID: 29296857; PubMed Central PMCID: PMC5728278.
 

Cavo M, Terpos E, Nanni C, Moreau P, Lentzsch S, Zweegman S, Hillengass J, Engelhardt M, Usmani SZ, Vesole DH, San-Miguel J, Kumar SK, Richardson PG, Mikhael JR, da Costa FL, Dimopoulos MA, Zingaretti C, Abildgaard N, Goldschmidt H, Orlowski RZ, Chng WJ, Einsele H, Lonial S, Barlogie B, Anderson KC, Rajkumar SV, Durie BGM, Zamagni E. Role of (18)F-FDG PET/CT in the diagnosis and management of multiple myeloma and other plasma cell disorders: a consensus statement by the International Myeloma Working Group. Lancet Oncol. 2017 Apr;18(4):e206-e217. doi: 10.1016/S1470-2045(17)30189-4. Review. PubMed PMID: 28368259.
 

Dimopoulos K, Søgaard Helbo A, Fibiger Munch-Petersen H, Sjö L, Christensen J, Sommer Kristensen L, Asmar F, Hermansen NEU, O'Connel C, Gimsing P, Liang G, Grønbaek K. Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon-independent manner. Mol Oncol. 2017 Nov 11. doi: 10.1002/1878-0261.12157. [Epub ahead of print] PubMed PMID: 29130642.
 

Gregersen H, Vangsted AJ, Abildgaard N, Andersen NF, Pedersen RS, Frølund UC, Helleberg C, Broch B, Pedersen PT, Gimsing P, Klausen TW. The impact of comorbidity on mortality in multiple myeloma: a Danish nationwide population-based study. Cancer Med. 2017 Jul;6(7):1807-1816. doi: 10.1002/cam4.1128. Epub 2017 Jun 22. PubMed PMID: 28639741; PubMed Central PMCID: PMC5504337.
 

Hillengass J, Moulopoulos LA, Delorme S, Koutoulidis V, Mosebach J, Hielscher T, Drake M, Rajkumar SV, Oestergaard B, Abildgaard N, Hinge M, Plesner T, Suehara Y, Matsue K, Withofs N, Caers J, Waage A, Goldschmidt H, Dimopoulos MA, Lentzsch S, Durie B, Terpos E. Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group. Blood Cancer J. 2017 Aug 25;7(8):e599. doi: 10.1038/bcj.2017.78. PubMed PMID: 28841211; PubMed Central PMCID: PMC5596388.
 

Krejcik J, Frerichs KA, Nijhof IS, van Kessel B, van Velzen JF, Bloem AC, Broekmans MEC, Zweegman S, van Meerloo J, Musters RJP, Poddighe PJ, Groen RWJ, Chiu C, Plesner T, Lokhorst HM, Sasser AK, Mutis T, van de Donk NWCJ. Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab. Clin Cancer Res. 2017 Dec 15;23(24):7498-7511. doi: 10.1158/1078-0432.CCR-17-2027. Epub 2017 Oct 12. PubMed PMID: 29025767; PubMed Central PMCID: PMC5732844.
 

Macauda A, Calvetti D, Maccari G, Hemminki K, Försti A, Goldschmidt H, Weinhold N, Houlston R, Andersen V, Vogel U, Buda G, Varkonyi J, Sureda A, Martinez Lopez J, Watek M, Butrym A, Sarasquete ME, Dudziński M, Jurczyszyn A, Druzd-Sitek A, Kruszewski M, Subocz E, Petrini M, Iskierka-Jażdżewska E, Raźny M, Szombath G, Marques H, Zawirska D, Chraniuk D, Halka J, Hove Jacobsen SE, Mazur G, García Sanz R, Dumontet C, Moreno V, Stępień A, Beider K, Pelosini M, Manuel Reis R, Krawczyk-Kulis M, Rymko M, Avet-Loiseau H, Lesueur F, Grząśko N, Ostrovsky O, Jamroziak K, Vangsted AJ, Jerez A, Tomczak W, Zaucha JM, Kadar K, Sainz J, Nagler A, Landi S, Gemignani F, Canzian F. Identification of miRSNPs associated with the risk of multiple myeloma. Int J Cancer. 2017 Feb 1;140(3):526-534. doi: 10.1002/ijc.30465. Epub 2016 Nov 9. PubMed PMID: 27718532.
 

Marcussen M, Bødker JS, Christensen HS, Johansen P, Nielsen S, Christiansen I, Bergmann OJ, Bøgsted M, Dybkær K, Vyberg M, Johnsen HE. Molecular Characteristics of High-Dose Melphalan Associated Oral Mucositis in Patients with Multiple Myeloma: A Gene Expression Study on Human Mucosa. PLoS One. 2017 Jan 4;12(1):e0169286. doi: 10.1371/journal.pone.0169286. eCollection 2017. PubMed PMID: 28052121; PubMed Central PMCID: PMC5215401.

Mateos MV, Masszi T, Grzasko N, Hansson M, Sandhu I, Pour L, Viterbo L, Jackson SR, Stoppa AM, Gimsing P, Hamadani M, Borsaru G, Berg D, Lin J, Di Bacco A, van de Velde H, Richardson PG, Moreau P. Impact of prior therapy on the efficacy and safety of oral ixazomib-lenalidomide-dexamethasone vs. placebo-lenalidomide-dexamethasone in patients with relapsed/refractory multiple myeloma in TOURMALINE-MM1. Haematologica. 2017 Oct;102(10):1767-1775. doi: 10.3324/haematol.2017.170118. Epub 2017 Jul 27. PubMed PMID: 28751562; PubMed Central PMCID: PMC5622861.

McCudden C, Axel AE, Slaets D, Dejoie T, Clemens P, Frans S, Bald J, Plesner T, Jacobs JF, van de Donk NW, Moreau P, Schecter JM, Ahmadi T, Sasser AK. Response to: Interference of daratumumab on the serum protein electrophoresis. Clin Chem Lab Med. 2017 Feb 1;55(2):e29-e30. doi: 10.1515/cclm-2016-1026. PubMed PMID: 27930366.

Nielsen LK, Jarden M, Andersen CL, Frederiksen H, Abildgaard N. A systematic review of health-related quality of life in longitudinal studies of myeloma patients. Eur J Haematol. 2017 Jul;99(1):3-17. doi: 10.1111/ejh.12882. Epub 2017 Apr 25. Review. PubMed PMID: 28322018.


Nielsen KR, Rodrigo-Domingo M, Steffensen R, Baech J, Bergkvist KS, Oosterhof L, Schmitz A, Bødker JS, Johansen P, Vogel U, Vangsted A, Dybkær K, Bøgsted M, Johnsen HE. Interactions between SNPs affecting inflammatory response genes are associated with multiple myeloma disease risk and survival. Leuk Lymphoma. 2017 Nov;58(11):2695-2704. doi: 10.1080/10428194.2017.1306643. Epub 2017 Apr 9. PubMed PMID: 28393658.

Sezer O, Beksac M, Hajek R, Sucak G, Cagirgan S, Linkesch W, Meltem Akay O, Gülbas Z, Nahi H, Plesner T, Snowden JA, Timurağaoğlu A, Dechow T, Lang A, Tuğlular T, Drach J, Armbrecht G, Potamianou A, Couturier C, Olie RA, Feys C, Allietta N, Terpos E. Effects of single-agent bortezomib as post-transplant consolidation therapy on multiple myeloma-related bone disease: a randomized phase II study. Br J Haematol. 2017 Jul;178(1):61-71. doi: 10.1111/bjh.14637. Epub 2017 Apr 6. PubMed PMID: 28382618.

Sørrig R, Klausen TW, Salomo M, Vangsted AJ, Frølund UC, Andersen KT, Klostergaard A, Helleberg C, Pedersen RS, Pedersen PT, Helm-Petersen S, Teodorescu EM, Preiss B, Abildgaard N, Gimsing P; Danish Myeloma Study Group. Immunoparesis in newly diagnosed Multiple Myeloma patients: Effects on overall survival and progression free survival in the Danish population. PLoS One. 2017 Dec 7;12(12):e0188988. doi: 10.1371/journal.pone.0188988. eCollection 2017. PubMed PMID: 29216227; PubMed Central PMCID: PMC5720701.

Thidemann Andersen K, Klausen T, Abildgaard N, Klarskov Andersen M, Frost Andersen N, Christian Frølund U, Helleberg C, Kjeldsen E, Pedersen P, Helm-Petersen S, Svirskaite A, Preiss B, Gimsing P, Juul Vangsted A. Causes of early death in multiple myeloma patients treated with high-dose therapy followed by autologous stem cell transplantation: A study based on the nationwide Danish Multiple Myeloma Registry. Am J Hematol. 2017 Oct;92(10):E611-E614. doi: 10.1002/ajh.24857. Epub 2017 Aug 17. PubMed PMID: 28707398.

 
Vangsted AJ, Helm-Petersen S, Cowland JB, Jensen PB, Gimsing P, Barlogie B, Knudsen S. Drug response prediction in high-risk multiple myeloma. Gene. 2018 Feb 20;644:80-86. doi: 10.1016/j.gene.2017.10.071. Epub 2017 Nov 6. PubMed PMID: 29122646.

 
Weisel K, Doyen C, Dimopoulos M, Yee A, Lahuerta JJ, Martin A, Travers K, Druyts E, Toor K, Abildgaard N, Lu J, Van Droogenbroeck J, Geraldes C, Petrini M, Voillat L, Voog E, Facon T. A systematic literature review and network meta-analysis of treatments for patients with untreated multiple myeloma not eligible for stem cell transplantation. Leuk Lymphoma. 2017 Jan;58(1):153-161. Epub 2016 Apr 28. Review. PubMed PMID: 27124703.

 
Xu XS, Yan X, Puchalski T, Lonial S, Lokhorst HM, Voorhees PM, Plesner T, Liu K, Khan I, Jansson R, Ahmadi T, Ruixo JP, Zhou H, Clemens PL. Clinical Implications of Complex Pharmacokinetics for Daratumumab Dose Regimen in Patients With Relapsed/Refractory Multiple Myeloma. Clin Pharmacol Ther. 2017 Jun;101(6):721-724. doi: 10.1002/cpt.577. Epub 2017 Feb 13. PubMed PMID: 27859027; PubMed Central PMCID: PMC5485722.

 
Yan X, Clemens PL, Puchalski T, Lonial S, Lokhorst H, Voorhees PM, Usmani S, Richardson PG, Plesner T, Liu K, Orlowski RZ, Losic N, Jansson R, Ahmadi T, Lantz K, Ruixo JJP, Zhou H, Xu XS. Influence of Disease and Patient Characteristics on Daratumumab Exposure and Clinical Outcomes in Relapsed or Refractory Multiple Myeloma. Clin Pharmacokinet. 2017 Oct 5. doi: 10.1007/s40262-017-0598-1. [Epub ahead of print] PubMed PMID: 28983805.

 

2016

Bieghs L, Johnsen HE, Maes K, Menu E, Van Valckenborgh E, Overgaard MT, Nyegaard M, Conover CA, Vanderkerken K, De Bruyne E. The insulin-like growth factor system in multiple myeloma: diagnostic and therapeutic potential. Oncotarget. 2016 Jul 26;7(30):48732-48752. doi: 10.18632/oncotarget.8982. Review. PubMed PMID: 27129151; PubMed Central PMCID: PMC5217049.

 

Bieghs L, Brohus M, Kristensen IB, Abildgaard N, Bøgsted M, Johnsen HE, Conover CA, De Bruyne E, Vanderkerken K, Overgaard MT, Nyegaard M. Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients. PloS One. 2016 Apr 25;11(4):e0154256. doi: 10.1371/journal.pone.0154256. PubMed PMID: 27111220; PubMed Central PMCID: PMC4844248.

 

Bilgrau AE, Falgreen S, Petersen A, Kjeldsen MK, Bødker JS, Johnsen HE, Dybkær K, Bøgsted M. Unaccounted uncertainty from qPCR efficiency estimates entails uncontrolled false positive rates. BMC Bioinformatics. 2016 Apr 11;17:159. doi: 10.1186/s12859-016-0997-6. PubMed PMID: 27067838; PubMed Central PMCID: PMC4827196.

 

Dimopoulos MA, Oriol A, Nahi H, San-Miguel J, Bahlis NJ, Usmani SZ, Rabin N, Orlowski RZ, Komarnicki M, Suzuki K, Plesner T, Yoon SS, Ben Yehuda D, Richardson PG, Goldschmidt H, Reece D, Lisby S, Khokhar NZ, O'Rourke L, Chiu C, Qin X, Guckert M, Ahmadi T, Moreau P; POLLUX Investigators.. Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma. N Engl J Med. 2016 Oct 6;375(14):1319-1331. PubMed PMID: 27705267.

 

Erickson SW, Stephens OW, Chavan SS, Epstein J, Barlogie B, Heuck CJ, Vangsted AJ. A common genetic variant in 19q13·3 is associated with outcome of multiple myeloma patients treated with Total Therapy 2 and 3. Br J Haematol. 2016 Sep;174(6):991-3. doi: 10.1111/bjh.13830. PubMed PMID: 26568154.

 

Erickson SW, Stephens OW, Chavan SS, Tian E, Epstein J, Barlogie B, Heuck CJ, Vangsted AJ. Common genetic variants in 11q13.3 and 9q22.33 are associated with molecular subgroups of multiple myeloma. Leukemia. 2015 Dec;29(12):2418-21. doi: 10.1038/leu.2015.238. PubMed PMID: 26308770.

 

Fu J, Li S, Feng R, Ma H, Sabeh F, Roodman GD, Wang J, Robinson S, Guo XE, Lund T, Normolle D, Mapara MY, Weiss SJ, Lentzsch S. Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease. J Clin Invest. 2016 May 2;126(5):1759-72. doi: 10.1172/JCI80276. PubMed PMID: 27043283; PubMed Central PMCID: PMC4855918.

 

Gimsing P, Holmström MO, Klausen TW, Andersen NF, Gregersen H, Pedersen RS, Plesner T, Pedersen PT, Frederiksen M, Frølund U, Helleberg C, Vangsted A, de Nully Brown P, Abildgaard N. The Danish National Multiple Myeloma Registry. Clin Epidemiol. 2016 Oct 25;8:583-587. Review. PubMed PMID: 27822103; PubMed Central PMCID: PMC5094522.

 

Hansen CT. Performance goals for immunoglobulins and serum free light chain measurements in plasma cell dyscrasias can be based on biological variation. Clinical Chemistry and Laboratory Medicine. 2016; 54: 1031-33.

 

Hermansen NE, Borup R, Andersen MK, Vangsted AJ, Clausen NT, Kristensen DL, Nielsen FC, Gimsing P. Gene expression risk signatures maintain prognostic power in multiple myeloma despite microarray probe set translation. Int J Lab Hematol. 2016 Jun;38(3):298-307. doi: 10.1111/ijlh.12486. PubMed PMID: 27027250.

 

Hinge M, Andersen KT, Lund T, Jørgensen HB, Holdgaard PC, Ormstrup TE, Østergaard LL, Plesner T. Baseline bone involvement in multiple myeloma – a prospective comparison of conventional X-ray, low-dose computed tomography, and 18flourodeoxyglucose positron emission tomography in previously untreated patients. Haematologica. 2016 Oct;101(10):e415-e418. PubMed PMID: 27390357; PubMed Central PMCID: PMC5046664.

 

Hinge M, Andersen KT, Lund T, Jørgensen HB, Holdgaard PC, Ormstrup TE, Østergaard LL, Plesner T. Bone healing in multiple myeloma: a prospective evaluation of the impact of first-line anti-myeloma treatment. Haematologica. 2016 Oct;101(10):e419-e422. PubMed PMID: 27365490; PubMed Central PMCID: PMC5046665.

 

Johnsen HE, Bøgsted M, Schmitz A, Bødker JS, El-Galaly TC, Johansen P, Valent P, Zojer N, Van Valckenborgh E, Vanderkerken K, van Duin M, Sonneveld P, Perez-Andres M, Orfao A, Dybkær K. The myeloma stem cell concept, revisited: from phenomenology to operational terms. Haematologica. 2016 Dec;101(12):1451-1459. Review. PubMed PMID: 27903712.

 

Jurczyszyn A, Grzasko N, Gozzetti A, Czepiel J, Cerase A, Hungria V, Crusoe E, Silva Dias AL, Vij R, Fiala MA, Caers J, Rasche L, Nooka AK, Lonial S, Vesole DH, Philip S, Gangatharan S, Druzd-Sitek A, Walewski J, Corso A, Cocito F, Vekemans MC, Atilla E, Beksac M, Leleu X, Davila J, Badros A, Aneja E, Abildgaard N, Kastritis E, Fantl D, Schutz N, Pika T, Butrym A, Olszewska-Szopa M, Usnarska-Zubkiewicz L, Usmani SZ, Nahi H, Chim CS, Shustik C, Madry K, Lentzsch S, Swiderska A, Helbig G, Guzicka-Kazimierczak R, Lendvai N, Waage A, Andersen KT, Murakami H, Zweegman S, Castillo JJ. Central nervous system involvement by multiple myeloma: A multi-institutional retrospective study of 172 patients in daily clinical practice. Am J Hematol. 2016 Jun;91(6):575-80. doi: 10.1002/ajh.24351. PubMed PMID: 26955792.

 

Jurczyszyn A, Nahi H, Avivi I, Gozzetti A, Niesvizky R, Yadlapati S, Jayabalan DS, Robak P, Pika T, Andersen KT, Rasche L, Mądry K, Woszczyk D, Raźny M, Usnarska-Zubkiewicz L, Knopińska-Posłuszny W, Wojciechowska M, Guzicka-Kazimierczak R, Joks M, Grosicki S, Ciepłuch H, Rymko M, Vesole DH, Castillo JJ. Characteristics and outcomes of patients with multiple myeloma aged 21-40 years versus 41-60 years: a multi-institutional case-control study. Br J Haematol. 2016 Dec;175(5):884-891. doi: 10.1111/bjh.14328. PubMed PMID: 27682187.

 

Jørgensen NG, Ahmad SM, Abildgaard N, Straten PT, Svane IM, Andersen MH, Knudsen LM. Peptide vaccination against multiple myeloma using peptides derived from anti-apoptotic proteins: a phase I trial. Stem Cell Investig. 2016 Dec 23;3:95. doi: 10.21037/sci.2016.11.09. PubMed PMID: 28078275; PubMed Central PMCID: PMC5222710.

 

Krejcik J, Casneuf T, Nijhof IS, Verbist B, Bald J, Plesner T, Syed K, Liu K, van de Donk NW, Weiss BM, Ahmadi T, Lokhorst HM, Mutis T, Sasser AK. Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma. Blood. 2016 Jul 21;128(3):384-94. doi: 10.1182/blood-2015-12-687749. PubMed PMID: 27222480; PubMed Central PMCID: PMC4957162.

 

Kumar S, Paiva B, Anderson KC, Durie B, Landgren O, Moreau P, Munshi N, Lonial S, Bladé J, Mateos MV, Dimopoulos M, Kastritis E, Boccadoro M, Orlowski R, Goldschmidt H, Spencer A, Hou J, Chng WJ, Usmani SZ, Zamagni E, Shimizu K, Jagannath S, Johnsen HE, Terpos E, Reiman A, Kyle RA, Sonneveld P, Richardson PG, McCarthy P, Ludwig H, Chen W, Cavo M, Harousseau JL, Lentzsch S, Hillengass J, Palumbo A, Orfao A, Rajkumar SV, San Miguel J, Avet-Loiseau H. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. Lancet Oncol. 2016 Aug;17(8):e328-46. doi: 10.1016/S1470-2045(16)30206-6. Review. PubMed PMID: 27511158.

 

Laubach J, Garderet L, Mahindra A, Gahrton G, Caers J, Sezer O, Voorhees P, Leleu X, Johnsen HE, Streetly M, Jurczyszyn A, Ludwig H, Mellqvist UH, Chng WJ, Pilarski L, Einsele H, Hou J, Turesson I, Zamagni E, Chim CS, Mazumder A, Westin J, Lu J, Reiman T, Kristinsson S, Joshua D, Roussel M, O'Gorman P, Terpos E, McCarthy P, Dimopoulos M, Moreau P, Orlowski RZ, Miguel JS, Anderson KC, Palumbo A, Kumar S, Rajkumar V, Durie B, Richardson PG. Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group. Leukemia. 2016 May;30(5):1005-17. doi: 10.1038/leu.2015.356. Review. PubMed PMID: 26710887.

 

Macauda A, Calvetti D, Maccari G, Hemminki K, Försti A, Goldschmidt H, Weinhold N, Houlston R, Andersen V, Vogel U, Buda G, Varkonyi J, Sureda A, Martinez Lopez J, Watek M, Butrym A, Sarasquete ME, Dudziński M, Jurczyszyn A, Druzd-Sitek A, Kruszewski M, Subocz E, Petrini M, Iskierka-Jażdżewska E, Raźny M, Szombath G, Marques H, Zawirska D, Chraniuk D, Halka J, Hove Jacobsen SE, Mazur G, García Sanz R, Dumontet C, Moreno V, Stępień A, Beider K, Pelosini M, Manuel Reis R, Krawczyk-Kulis M, Rymko M, Avet-Loiseau H, Lesueur F, Grząśko N, Ostrovsky O, Jamroziak K, Vangsted AJ, Jerez A, Tomczak W, Zaucha JM, Kadar K, Sainz J, Nagler A, Landi S, Gemignani F, Canzian F. Identification of miRSNPs associated with the risk of multiple myeloma. Int J Cancer. 2017 Feb 1;140(3):526-534. doi: 10.1002/ijc.30465. PubMed PMID: 27718532.

 

McCudden C, Axel AE, Slaets D, Dejoie T, Clemens PL, Frans S, Bald J, Plesner T, Jacobs JF, van de Donk NW, Moreau P, Schecter JM, Ahmadi T, Sasser AK.Monitoring multiple myeloma patients treated with daratumumab: teasing out monoclonal antibody interference. Clin Chem Lab Med. 2016 Jun 1;54(6):1095-104. doi: 10.1515/cclm-2015-1031. PubMed PMID: 27028734.

 

Mitchell JS, Li N, Weinhold N, Försti A, Ali M, van Duin M, Thorleifsson G, Johnson DC, Chen B, Halvarsson BM, Gudbjartsson DF, Kuiper R, Stephens OW, Bertsch U, Broderick P, Campo C, Einsele H, Gregory WA, Gullberg U, Henrion M, Hillengass J, Hoffmann P, Jackson GH, Johnsson E, Jöud M, Kristinsson SY, Lenhoff S, Lenive O, Mellqvist UH, Migliorini G, Nahi H, Nelander S, Nickel J, Nöthen MM, Rafnar T, Ross FM, da Silva Filho MI, Swaminathan B, Thomsen H, Turesson I, Vangsted A, Vogel U, Waage A, Walker BA, Wihlborg AK, Broyl A, Davies FE,Thorsteinsdottir U, Langer C, Hansson M, Kaiser M, Sonneveld P, Stefansson K, Morgan GJ, Goldschmidt H, Hemminki K, Nilsson B, Houlston RS. Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Nat Commun. 2016 Jul 1;7:12050. doi: 10.1038/ncomms12050. PubMed PMID: 27363682; PubMed Central PMCID: PMC4932178.

 

Moreau P, van de Donk NW, San Miguel J, Lokhorst H, Nahi H, Ben-Yehuda D, Cavo M, Cook G, Delforge M, Einsele H, Zweegman S, Ludwig H, Driessen C, Palumbo A, Facon T, Plesner T, Dimopoulos M, Sondergeld P, Sonneveld P, Mateos MV. Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma. Drugs. 2016 May;76(8):853-67. doi: 10.1007/s40265-016-0573-4. Erratum in: Drugs. 2016 Jun;76(9):989-90. PubMed PMID: 27113582.

 

Moreau P, van de Donk NW, Miguel JS, Lokhorst H, Nahi H, Ben-Yehuda D, Cavo M, Cook G, Delforge M, Einsele H, Zweegman S, Ludwig H, Driessen C, Palumbo A, Facon T, Plesner T, Dimopoulos M, Sondergeld P, Sonneveld P, Mateos MV. Erratum to: Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma. Drugs. 2016 Jun;76(9):989-990. PubMed PMID: 27206917.

 

Moreau P, Masszi T, Grzasko N, Bahlis NJ, Hansson M, Pour L, Sandhu I, Ganly P, Baker BW, Jackson SR, Stoppa AM, Simpson DR, Gimsing P, Palumbo A, Garderet L, Cavo M, Kumar S, Touzeau C, Buadi FK, Laubach JP, Berg DT, Lin J, Di Bacco A, Hui AM, van de Velde H, Richardson PG; TOURMALINE-MM1 Study Group.. Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma. N Engl J Med. 2016 Apr 28;374(17):1621-34. doi: 10.1056/NEJMoa1516282. PubMed PMID: 27119237.

 

Ocias LF, Larsen TS, Vestergaard H, Friis LS, Abildgaard N, Frederiksen H; Academy of Geriatric Cancer Research (AgeCare).. Trends in hematological cancer in the elderly in Denmark, 1980-2012. Acta Oncol. 2016;55 Suppl 1:98-107. doi: 10.3109/0284186X.2015.1115124. PubMed PMID: 26783877.

 

Petersen H., Holdgaard PC, Madsen, PH., Knudsen LM, Gad D, Gravergaard AE, Rohde M, Godballe C, Engelmann BE, Bech K, Teilmann-Jørgensen D, Mogensen O, Karstoft J, Johansen J, Christensen JB, Johansen A, Høilund-Carlsen PF. & PET/CT Task Force of the Region of Southern Denmark 2016. FDG PET/CT in cancer: comparison of actual use with literature-based recommendations European Journal of Nuclear Medicine and Molecular Imaging. 2016; 43: 695–706

 

Plesner T, Arkenau HT, Gimsing P, Krejcik J, Lemech C, Minnema MC, Lassen U, Laubach JP, Palumbo A, Lisby S, Basse L, Wang J, Sasser AK, Guckert ME, de Boer C, Khokhar NZ, Yeh H, Clemens PL, Ahmadi T, Lokhorst HM, Richardson PG. Phase 1-2 study of daratumumab, lenalidomide, and dexamethasone for relapsed multiple myeloma. Blood. 2016 Aug 16. pii: blood-2016-07-726729. [Epub ahead of print] PubMed PMID: 27531679; PubMed Central PMCID: PMC5054695.

 

Ríos-Tamayo R, Lupiañez CB, Campa D, Hielscher T, Weinhold N, Martínez-López J, Jerez A, Landi S, Jamroziak K, Dumontet C, Wątek M, Lesueur F, Reis RM, Marques H, Jurczyszyn A, Vogel U, Buda G, García-Sanz R, Orciuolo E, Petrini M, Vangsted AJ, Gemignani F, Försti A, Goldschmidt H, Hemminki K, Canzian F, Jurado M, Sainz J. A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis. Oncotarget. 2016 Sep 13;7(37):59029-59048. doi: 10.18632/oncotarget.10665. PubMed PMID: 27437873.

 

Sørrig R, Klausen TW, Salomo M, Vangsted AJ, Østergaard B, Gregersen H, Frølund UC, Andersen NF, Helleberg C, Andersen KT, Pedersen RS, Pedersen P, Abildgaard N, Gimsing P; Danish Myeloma Study Group.. Smoldering multiple myeloma risk factors for progression: a Danish population-based cohort study. Eur J Haematol. 2016 Sep;97(3):303-9. doi: 10.1111/ejh.12728. PubMed PMID: 26710662.

 

Usmani SZ, Weiss BM, Plesner T, Bahlis NJ, Belch A, Lonial S, Lokhorst HM, Voorhees PM, Richardson PG, Chari A, Sasser AK, Axel A, Feng H, Uhlar CM, Wang J, Khan I, Ahmadi T, Nahi H. Clinical efficacy of daratumumab monotherapy in patients with heavily pretreated relapsed or refractory multiple myeloma. Blood. 2016 Jul 7;128(1):37-44. doi: 10.1182/blood-2016-03-705210. PubMed PMID: 27216216; PubMed Central PMCID: PMC4937359.

 

van de Donk NW, Moreau P, Plesner T, Palumbo A, Gay F, Laubach JP, Malavasi F, Avet-Loiseau H, Mateos MV, Sonneveld P, Lokhorst HM, Richardson PG. Clinical efficacy and management of monoclonal antibodies targeting CD38 and SLAMF7 in multiple myeloma. Blood. 2016 Feb 11;127(6):681-95. doi: 10.1182/blood-2015-10-646810. Review. PubMed PMID: 26631114.

 

Xu XS, Yan X, Puchalski T, Lonial S, Lokhorst HM, Voorhees PM, Plesner T, Liu K, Khan I, Jansson R, Ahmadi T, Perez Ruixo JJ, Zhou H, Clemens PL. Clinical Implications of Complex Pharmacokinetics for Daratumumab Dose Regimen in Patients With Relapsed/Refractory Multiple Myeloma. Clin Pharmacol Ther. 2016 Nov 17. doi: 10.1002/cpt.577. [Epub ahead of print] PubMed PMID: 27859027.

Zweegman S, van der Holt B, Mellqvist UH, Salomo M, Bos GM, Levin MD, Visser-Wisselaar H, Hansson M, van der Velden AW, Deenik W, Gruber A, Coenen JL, Plesner T, Klein SK, Tanis BC, Szatkowski DL, Brouwer RE, Westerman M, Leys MR, Sinnige HA, Haukås E, van der Hem KG, Durian MF, Mattijssen EV, van de Donk NW, Stevens-Kroef MJ, Sonneveld P, Waage A. Melphalan, prednisone, and lenalidomide versus melphalan, prednisone, and thalidomide in untreated multiple myeloma. Blood. 2016 Mar 3;127(9):1109-16. doi: 10.1182/blood-2015-11-679415. PubMed PMID: 26802176.

 

 

2014

Al-Zuhairy A, Schrøder HD, Plesner T, Abildgaard N, Sindrup SH. Immunostaining of skin biopsy adds no diagnostic value in MGUS-associated peripheral neuropathy. J Neurol Sci. 2014 Dec 26. pii: S0022-510X(14)00791-6. doi: 10.1016/j.jns.2014.12.026. [Epub ahead of print] PubMed PMID: 25582978.

Andersen MN, Abildgaard N, Maniecki MB, Møller HJ, Andersen NF. Monocyte/macrophage-derived soluble CD163: a novel biomarker in multiple myeloma. Eur J Haematol. 2014 Jul;93(1):41-7. doi: 10.1111/ejh.12296. Epub 2014 Mar 20. PubMed PMID: 24612259.

Andersen NF, Kristensen IB, Preiss BS, Christensen JH, Abildgaard N. Upregulation of Syndecan-1 in the bone marrow microenvironment in multiple myeloma is associated with angiogenesis. Eur J Haematol. 2014 Oct 29. doi: 10.1111/ejh.12473. [Epub ahead of print] PubMed PMID: 25353275.

Andersen NF, Vogel U, Klausen TW, Gimsing P, Gregersen H, Abildgaard N, Vangsted AJ. Polymorphisms in the heparanase gene in multiple myeloma association with bone morbidity and survival. Eur J Haematol. 2014 Jun 21. doi: 10.1111/ejh.12401. [Epub ahead of print] PubMed PMID: 24954766.

Bieghs L, Lub S, Fostier K, Maes K, Van Valckenborgh E, Menu E, Johnsen HE, Overgaard MT, Larsson O, Axelson M, Nyegaard M, Schots R, Jernberg-Wiklund H, Vanderkerken K, De Bruyne E. The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic. Oncotarget. 2014 Nov 30;5(22):11193-208. PubMed PMID: 25008202; PubMed Central PMCID: PMC4294345.

Campa D, Martino A, Varkonyi J, Lesueur F, Jamroziak K, Landi S, Jurczyszyn A, Marques H, Andersen V, Jurado M, Brenner H, Petrini M, Vogel U, García-Sanz R, Buda G, Gemignani F, Ríos R, Vangsted AJ, Dumontet C, Martínez-López J, Moreno MJ, Stępień A, Wątek M, Moreno V, Dieffenbach AK, Rossi AM, Butterbach K, Jacobsen SE, Goldschmidt H, Sainz J, Hillengass J, Orciuolo E, Dudziński M, Weinhold N, Reis RM, Canzian F. Risk of multiple myeloma is associated with polymorphisms within telomerase genes and telomere length. Int J Cancer. 2015 Mar 1;136(5):E351-8. doi: 10.1002/ijc.29101. Epub 2014 Aug 6. PubMed PMID: 25066524.

Coleman EA, Lee JY, Erickson SW, Goodwin JA, Sanathkumar N, Raj VR, Zhou D, McKelvey KD, Apewokin S, Stephens O, Enderlin CA, Vangsted AJ, Reed PJ, Anaissie  EJ. GWAS of 972 autologous stem cell recipients with multiple myeloma identifies  11 genetic variants associated with chemotherapy-induced oral mucositis. Support  Care Cancer. 2015 Mar;23(3):841-9. doi: 10.1007/s00520-014-2406-x. Epub 2014 Sep  14. PubMed PMID: 25218607.

Dimopoulos K, Gimsing P, Grønbæk K. The role of epigenetics in the biology of  multiple myeloma. Blood Cancer J. 2014 May 2;4:e207. doi: 10.1038/bcj.2014.29. PubMed PMID: 24786391; PubMed Central PMCID: PMC4042299.

DMSG. Årsrapport 2013 for Dansk Myelomatose Studie Gruppe og den landsdækkende myelomatose databasewww.myeloma.dk

Engelhardt M, Terpos E, Kleber M, Gay F, Wäsch R, Morgan G, Cavo M, van de Donk N, Beilhack A, Bruno B, Johnsen HE, Hajek R, Driessen C, Ludwig H, Beksac M, Boccadoro M, Straka C, Brighen S, Gramatzki M, Larocca A, Lokhorst H, Magarotto V, Morabito F, Dimopoulos MA, Einsele H, Sonneveld P, Palumbo A; European Myeloma Network. European Myeloma Network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma. Haematologica. 2014 Feb;99(2):232-42. doi: 10.3324/haematol.2013.099358. PubMed PMID: 24497560; PubMed Central PMCID: PMC3912952.

Erickson SW, Raj VR, Stephens OW, Dhakal I, Chavan SS, Sanathkumar N, Coleman EA, Lee JY, Goodwin JA, Apewokin S, Zhou D, Epstein J, Heuck CJ, Vangsted AJ.  Genome-wide scan identifies variant in 2q12.3 associated with risk for multiple myeloma. Blood. 2014 Sep 18;124(12):2001-3. doi: 10.1182/blood-2014-07-586701. PubMed PMID: 25237182.

Falgreen S, Laursen MB, Bødker JS, Kjeldsen MK, Schmitz A, Nyegaard M, Johnsen HE, Dybkær K, Bøgsted M. Exposure time independent summary statistics for assessment of drug dependent cell line growth inhibition. BMC Bioinformatics. 2014 Jun 5;15:168. doi: 10.1186/1471-2105-15-168. PubMed PMID: 24902483; PubMed Central PMCID: PMC4127655.

Godskesen L, Abildgaard N, Kjeldsen J, Krag A. A rare cause of severe hepatomegaly with an improving outcome. BMJ Case Rep. 2014 Apr 3;2014. pii: bcr2013203360. doi: 10.1136/bcr-2013-203360. PubMed PMID: 24700044.

Hansen CT, Pedersen PT, Nielsen LC, Abildgaard N. Evaluation of the serum free light chain (sFLC) analysis in prediction of response in symptomatic multiple myeloma patients: rapid profound reduction in involved FLC predicts achievement of VGPR. Eur J Haematol. 2014 Nov;93(5):407-13. doi: 10.1111/ejh.12376. Epub 2014 Jun 14. PubMed PMID: 24809596.

Hansen CT, Abildgaard N. Biological variation of free light chains in serum. Clin Chim Acta. 2014 Jan 1;427:27-8. doi: 10.1016/j.cca.2013.09.020. Epub 2013 Oct 1. PubMed PMID: 24091097.

Johnsen HE, Bergkvist KS, Schmitz A, Kjeldsen MK, Hansen SM, Gaihede M, Nørgaard MA, Bæch J, Grønholdt ML, Jensen FS, Johansen P, Bødker JS, Bøgsted M, Dybkær K; Myeloma Stem Cell Network (MSCNET). Cell of origin associated classification of B-cell malignancies by gene signatures of the normal B-cell hierarchy. Leuk Lymphoma. 2014 Jun;55(6):1251-60. doi: 10.3109/10428194.2013.839785. Epub 2013 Nov 1. PubMed PMID: 23998255.

Kristensen IB, Christensen JH, Lyng MB, Møller MB, Pedersen L, Rasmussen LM, Ditzel HJ, Abildgaard N. Expression of osteoblast and osteoclast regulatory genes in the bone marrow microenvironment in multiple myeloma: only up-regulation of Wnt inhibitors SFRP3 and DKK1 is associated with lytic bone disease. Leuk Lymphoma. 2014 Apr;55(4):911-9. doi: 10.3109/10428194.2013.820288. Epub 2013 Aug  5. PubMed PMID: 23915193.

Laursen MB, Falgreen S, Bødker JS, Schmitz A, Kjeldsen MK, Sørensen S, Madsen J, El-Galaly TC, Bøgsted M, Dybkær K, Johnsen HE; Myeloma Stem Cell Network. Human B-cell cancer cell lines as a preclinical model for studies of drug effect  in diffuse large B-cell lymphoma and multiple myeloma. Exp Hematol. 2014 Nov;42(11):927-38. doi: 10.1016/j.exphem.2014.07.263. Epub 2014 Jul 27. Review. PubMed PMID: 25072621.

Ludwig H, Sonneveld P, Davies F, Bladé J, Boccadoro M, Cavo M, Morgan G, de la Rubia J, Delforge M, Dimopoulos M, Einsele H, Facon T, Goldschmidt H, Moreau P, Nahi H, Plesner T, San-Miguel J, Hajek R, Sondergeld P, Palumbo A. European perspective on multiple myeloma treatment strategies in 2014. Oncologist. 2014 Aug;19(8):829-44. doi: 10.1634/theoncologist.2014-0042. Epub 2014 Jul 25. PubMed  PMID: 25063227; PubMed Central PMCID: PMC4122482.

Martino A, Campa D, Jurczyszyn A, Martínez-López J, Moreno MJ, Varkonyi J, Dumontet C, García-Sanz R, Gemignani F, Jamroziak K, Stępieł A, Jacobsen SE, Andersen V, Jurado M, Landi S, Rossi AM, Lesueur F, Marques H, Dudziński M, Wątek M, Moreno V, Orciuolo E, Petrini M, Reis RM, Ríos R, Sainz J, Vogel U, Buda G, Vangsted AJ, Canzian F. Genetic variants and multiple myeloma risk: IMMEnSE validation of the best reported associations--an extensive replication of the associations from the candidate gene era. Cancer Epidemiol Biomarkers Prev. 2014  Apr;23(4):670-4. doi: 10.1158/1055-9965.EPI-13-1115. Epub 2014 Feb 12. PubMed PMID: 24521996.

Morabito F, Bringhen S, Larocca A, Wijermans P, Victoria Mateos M, Gimsing P, Mazzone C, Gottardi D, Omedè P, Zweegman S, José Lahuerta J, Zambello R, Musto P, Magarotto V, Schaafsma M, Oriol A, Juliusson G, Cerrato C, Catalano L, Gentile M, Isabel Turel A, Marina Liberati A, Cavalli M, Rossi D, Passera R, Rosso S, Beksac M, Cavo M, Waage A, San Miguel J, Boccadoro M, Sonneveld P, Palumbo A, Offidani M. Bortezomib, melphalan, prednisone (VMP) versus melphalan, prednisone, thalidomide (MPT) in elderly newly diagnosed multiple myeloma patients: A retrospective case-matched study. Am J Hematol. 2014 Apr;89(4):355-62. doi: 10.1002/ajh.23641. Epub 2014 Feb 5. PubMed PMID: 24273190.

Nelson LM, Gustafsson F, Gimsing P. Characteristics and Long-Term Outcome of Patients with Systemic Immunoglobulin Light-Chain Amyloidosis. Acta Haematol. 2014 Dec 16;133(4):336-346. [Epub ahead of print] PubMed PMID: 25531398.

Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, Landgren O, Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jagannath S, Sezer  O, Kristinsson SY, Caers J, Usmani SZ, Lahuerta JJ, Johnsen HE, Beksac M, Cavo M, Goldschmidt H, Terpos E, Kyle RA, Anderson KC, Durie BG, Miguel JF. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014 Nov;15(12):e538-48. doi: 10.1016/S1470-2045(14)70442-5. Epub 2014 Oct 26. PubMed PMID: 25439696.

Rasmussen SM, Bilgrau AE, Schmitz A, Falgreen S, Bergkvist KS, Tramm AM, Baech J, Jacobsen CL, Gaihede M, Kjeldsen MK, Bødker JS, Dybkaer K, Bøgsted M, Johnsen HE. Stable Phenotype Of B-Cell Subsets Following Cryopreservation and Thawing of Normal Human Lymphocytes Stored in a Tissue Biobank. Cytometry B Clin Cytom. 2014 Sep 20. doi: 10.1002/cytob.21192. [Epub ahead of print] PubMed PMID:  25242153.

Rodrigo-Domingo M, Waagepetersen R, Bødker JS, Falgreen S, Kjeldsen MK, Johnsen HE, Dybkær K, Bøgsted M. Reproducible probe-level analysis of the Affymetrix Exon 1.0 ST array with R/Bioconductor. Brief Bioinform. 2014 Jul;15(4):519-33. PubMed PMID: 23603090; PubMed Central PMCID: PMC4103539.

San-Miguel JF, Hungria VT, Yoon SS, Beksac M, Dimopoulos MA, Elghandour A, Jedrzejczak WW, Günther A, Nakorn TN, Siritanaratkul N, Corradini P, Chuncharunee S, Lee JJ, Schlossman RL, Shelekhova T, Yong K, Tan D, Numbenjapon T, Cavenagh JD, Hou J, LeBlanc R, Nahi H, Qiu L, Salwender H, Pulini S, Moreau P, Warzocha K, White D, Bladé J, Chen W, de la Rubia J, Gimsing P, Lonial S, Kaufman JL, Ocio EM, Veskovski L, Sohn SK, Wang MC, Lee JH, Einsele H, Sopala M, Corrado C, Bengoudifa BR, Binlich F, Richardson PG. Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial. Lancet Oncol. 2014 Oct;15(11):1195-206. doi: 10.1016/S1470-2045(14)70440-1. Epub 2014 Sep 18. PubMed PMID: 25242045.

Simony A, Hansen EJ, Gaurilcikas M, Abildgaard N, Andersen MØ. Pain reduction after percutaneous vertebroplasty for myeloma-associated vertebral fractures. Dan Med J. 2014 Dec;61(12):A4945. PubMed PMID: 25441724.

Søe K, Delaissé JM, Jakobsen EH, Hansen CT, Plesner T. Dosing related effects of zoledronic acid on bone markers and creatinine clearance in patients with multiple myeloma and metastatic breast cancer. Acta Oncol. 2014 Apr;53(4):547-56. doi: 10.3109/0284186X.2013.844358. Epub 2013 Oct 28. PubMed PMID: 24164102.

Van de Donk NW, Palumbo A, Johnsen HE, Engelhardt M, Gay F, Gregersen H, Hajek R, Kleber M, Ludwig H, Morgan G, Musto P, Plesner T, Sezer O, Terpos E, Waage A, Zweegman S, Einsele H, Sonneveld P, Lokhorst HM; European Myeloma Network. The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network. Haematologica. 2014 Jun;99(6):984-96. doi: 10.3324/haematol.2013.100552. Epub 2014 Mar 21. PubMed PMID: 24658815; PubMed Central PMCID: PMC4040895.

Vangsted AJ, Klausen TW, Gimsing P, Abildgaard N, Andersen NF, Gang AO, Holmström M, Gregersen H, Vogel U, Schwarz P, Jørgensen NR. Genetic variants in the P2RX7 gene are associated with risk of multiple myeloma. Eur J Haematol. 2014 Aug;93(2):172-4. doi: 10.1111/ejh.12353. Epub 2014 May 17. PubMed PMID: 24766221.

2013

Blijlevens N, de Château M, Krivan G, Rabitsch W, Szomor A, Pytlik R, Lissmats, A, Johnsen HE, de Witte T, Einsele H, Ruutu T, Niederwieser D; CLWP of the EBMT. In a high-dose melphalan setting, palifermin compared with placebo had no effect on oral mucositis or related patient's burden. Bone Marrow Transplant. 2013 Jul;48(7):966-71. doi: 10.1038/bmt.2012.257. Epub 2012 Dec 17. PubMed PMID:23241739.

Bødker JS, Gyrup C, Johansen P, Schmitz A, Madsen J, Johnsen HE, Bøgsted M, Dybkær K, Nyegaard M. Performance comparison of Affymetrix SNP6.0 and cytogenetic 2.7M whole-genome microarrays in complex cancer samples. Cytogenet Genome Res. 2013;139(2):80-7. doi: 10.1159/000345125. Epub 2012 Nov 20. PubMed PMID: 23182917.

Dabrowska MJ, Ejegod D, Lassen LB, Johnsen HE, Wabl M, Pedersen FS, Dybkær K. Gene expression profiling of murine T-cell lymphoblastic lymphoma identifies deregulation of S-phase initiating genes. Leuk Res. 2013 Oct;37(10):1383-90. doi:10.1016/j.leukres.2013.04.012. Epub 2013 Jul 26. PubMed PMID: 23896059.

Dimopoulos K, Gimsing P, Grønbæk K. Aberrant microRNA expression in multiple myeloma. Eur J Haematol. 2013 Aug;91(2):95-105. doi: 10.1111/ejh.12124. Epub 2013 Jun 5. Review. PubMed PMID: 23586898.

Fernández de Larrea C, Kyle RA, Durie BG, Ludwig H, Usmani S, Vesole DH, Hajek R, San Miguel JF, Sezer O, Sonneveld P, Kumar SK, Mahindra A, Comenzo R, Palumbo A, Mazumber A, Anderson KC, Richardson PG, Badros AZ, Caers J, Cavo M, LeLeu X, Dimopoulos MA, Chim CS, Schots R, Noeul A, Fantl D, Mellqvist UH, Landgren O, Chanan-Khan A, Moreau P, Fonseca R, Merlini G, Lahuerta JJ, Bladé J, Orlowski RZ, Shah JJ; International Myeloma Working Group. Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group. Leukemia. 2013 Apr;27(4):780-91. doi: 10.1038/leu.2012.336. Epub 2012 Nov 21. Review. PubMed PMID: 23288300.

Gregersen H, Larsen CB, Haglund A, Mortensen R, Andersen NF, Nørgaard M. Data quality of the monoclonal gammopathy of undetermined significance diagnosis in a hospital registry. Clin Epidemiol. 2013 Aug 27;5:321-6. doi: 10.2147/CLEP.S50757. eCollection 2013. PubMed PMID: 24009431; PubMed Central PMCID: PMC3762761.

Johnsen HE, Bergkvist KS, Schmitz A, Kjeldsen MK, Hansen SM, Gaihede M, Nørgaard MA, Bæch J, Grønholdt ML, Jensen FS, Johansen P, Bødker JS, Bøgsted M, Dybkær K; for the Myeloma Stem Cell Network (Mscnet). Cell of origin associated classification of B-cell malignancies by gene signatures of the normal B-cell hierarchy. Leuk Lymphoma. 2013 Nov 1. [Epub ahead of print] PubMed PMID:23998255.

Kaltoft B, Schmidt G, Lauritzen AF, Gimsing P. Primary localised cutaneous amyloidosis--a systematic review. Dan Med J. 2013 Nov;60(11):A4727. PubMed PMID: 24192243.

Kristensen IB, Pedersen L, Rø TB, Christensen JH, Lyng MB, Rasmussen LM, Ditzel HJ, Børset M, Abildgaard N. Decorin is down-regulated in multiple myeloma and MGUS bone marrow plasma and inhibits HGF-induced myeloma plasma cell viability and migration. Eur J Haematol. 2013 Sep;91(3):196-200. doi:10.1111/ejh.12125. Epub 2013 Jul 7. PubMed PMID: 23607294.

Kristensen IB, Christensen JH, Lyng MB, Møller MB, Pedersen L, Rasmussen LM, Ditzel HJ, Abildgaard N. Hepatocyte growth factor pathway upregulation in the bone marrow microenvironment in multiple myeloma is associated with lytic bone disease. Br J Haematol. 2013 May;161(3):373-82. doi: 10.1111/bjh.12270. Epub 2013Feb 22. PubMed PMID: 23431957.

Kristensen IB, Christensen JH, Lyng MB, Møller MB, Pedersen L, Rasmussen LM, Ditzel HJ, Abildgaard N. Expression of osteoblast and osteoclast regulatory genes in the bone marrow microenvironment in multiple myeloma: only up-regulation of Wnt inhibitors SFRP3 and DKK1 is associated with lytic bone disease. Leuk Lymphoma. 2013 Aug 5. [Epub ahead of print] PubMed PMID: 23915193.

Lanza F, Campioni DC, Hellmann A, Milone G, Wahlin A, Walewski J, Spedini P, Fiamenghi C, Cuneo A, Knopińska W, Swierkowska-Czeneszew M, Petriz J, Fruehauf S, Farge D, Mohty M, Passweg J, Ruuto T, Madrigal A, Johnsen HE; Quality Assessment of Haematopoietic Stem Cell Grafting Committee of European Blood and Marrow Transplantation Society. Individual quality assessment of autografting by probability estimation for clinical endpoints: a prospective validation study from the European group for blood and marrow transplantation. Biol Blood Marrow Transplant. 2013 Dec;19(12):1670-6. doi: 10.1016/j.bbmt.2013.08.005. Epub 2013Aug 27. PubMed PMID: 23988403.

Mellqvist UH, Gimsing P, Hjertner O, Lenhoff S, Laane E, Remes K, Steingrimsdottir H, Abildgaard N, Ahlberg L, Blimark C, Dahl IM, Forsberg K, Gedde-Dahl T, Gregersen H, Gruber A, Guldbrandsen N, Haukås E, Carlson K, Kvam AK, Nahi H, Lindås R, Andersen NF, Turesson I, Waage A, Westin J; Nordic Myeloma Study Group. Bortezomib consolidation after autologous stem cell transplantation in multiple myeloma: a Nordic Myeloma Study Group randomized phase 3 trial. Blood. 2013 Jun 6;121(23):4647-54. doi: 10.1182/blood-2012-11-464503. Epub 2013 Apr 24. PubMed PMID: 23616624; PubMed Central PMCID: PMC3674665.

Morabito F, Bringhen S, Larocca A, Wijermans P, Victoria Mateos M, Gimsing P, Mazzone C, Gottardi D, Omedè P, Zweegman S, José Lahuerta J, Zambello R, Musto P, Magarotto V, Schaafsma M, Oriol A, Juliusson G, Cerrato C, Catalano L, Gentile M, Isabel Turel A, Marina Liberati A, Cavalli M, Rossi D, Passera R, Rosso S, Beksac M, Cavo M, Waage A, San Miguel J, Boccadoro M, Sonneveld P, Palumbo A, Offidani M. Bortezomib, melphalan, prednisone (VMP) versus melphalan, prednisone, thalidomide (MPT) in elderly newly diagnosed multiple myeloma patients: A retrospective case-matched study. Am J Hematol. 2013 Nov 25. doi: 10.1002/ajh.23641. [Epub ahead of print] PubMed PMID: 24273190.

Palumbo A, Waage A, Hulin C, Beksac M, Zweegman S, Gay F, Gimsing P, Leleu X, Wijermans P, Sucak G, Pezzatti S, Juliusson G, Pégourié B, Schaafsma M, Galli M, Turesson I, Kolb B, van der Holt B, Baldi I, Rolke J, Ciccone G, Wetterwald M, Lokhorst H, Boccadoro M, Rodon P, Sonneveld P. Safety of thalidomide in newly diagnosed elderly myeloma patients: a meta-analysis of data from individual patients in six randomized trials. Haematologica. 2013 Jan;98(1):87-94. doi: 10.3324/haematol.2012.067058. Epub 2012 Aug 8. PubMed PMID: 22875621; PubMed Central PMCID: PMC3533664.

Popat R, Plesner T, Davies F, Cook G, Cook M, Elliott P, Jacobson E, Gumbleton T, Oakervee H, Cavenagh J. A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma. Br J Haematol. 2013 Mar;160(5):714-7. doi: 10.1111/bjh.12154. Epub 2012 Dec 4. PubMed PMID: 23205612.

Rodrigo-Domingo M, Waagepetersen R, Bødker JS, Falgreen S, Kjeldsen MK, Johnsen HE, Dybkær K, Bøgsted M. Reproducible probe-level analysis of the Affymetrix Exon 1.0 ST array with R/Bioconductor. Brief Bioinform. 2013 Apr 29. [Epub ahead of print] PubMed PMID: 23603090.

Søe K, Delaissé JM, Jakobsen EH, Hansen CT, Plesner T. Dosing related effectsof zoledronic acid on bone markers and creatinine clearance in patients with multiple myeloma and metastatic breast cancer. Acta Oncol. 2013 Oct 28. [Epub ahead of print] PubMed PMID: 24164102.

Søe K, Plesner T, Jakobsen EH, Hansen CT, Jørgensen HB, Delaissé JM. Is retention of zoledronic acid onto bone different in multiple myeloma and breast cancer patients with bone metastasis? J Bone Miner Res. 2013 Aug;28(8):1738-50. doi: 10.1002/jbmr.1897. PubMed PMID: 23427025.

Sørrig R, Hermansen NE, Hother C, Gimsing P. CD138+ cell separation affects cancer gene expression in human myeloma cell lines. Eur J Haematol. 2013 Aug;91(2):187-8. doi: 10.1111/ejh.12120. Epub 2013 Jun 5. PubMed PMID: 23581887.

2012

Andersen NF, Vogel U, Klausen TW, Gimsing P, Gregersen H, Abildgaard N,Vangsted AJ. Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalidomide in multiple myeloma. Int J Cancer. 2012 Sep 1;131(5):E636-42. doi: 10.1002/ijc.27387. Epub 2012 Jan 31. PubMed PMID:22139971.

Blijlevens N, de Château M, Krivan G, Rabitsch W, Szomor A, Pytlik R, Lissmats A, Johnsen HE, de Witte T, Einsele H, Ruutu T, Niederwieser D. In a high-dose melphalan setting, palifermin compared with placebo had no effect on oral mucositis or related patient's burden. Bone Marrow Transplant. 2012 Dec 17. doi: 10.1038/bmt.2012.257. [Epub ahead of print] PubMed PMID: 23241739.

Brown Pde N, Nørgaard JM, Gimsing P, Hasselbalch H, Abildgård N, Jensen P, Bukh A. [The Haematological Corporate Database]. Ugeskr Laeger. 2012 Oct 15;174(42):2526. Danish. PubMed PMID: 23079429.

Bødker JS, Gyrup C, Johansen P, Schmitz A, Madsen J, Johnsen HE, Bøgsted M, Dybkær K, Nyegaard M. Performance Comparison of Affymetrix SNP6.0 and Cytogenetic 2.7M Whole-Genome Microarrays in Complex Cancer Samples. Cytogenet Genome Res. 2013;139(2):80-7. doi: 10.1159/000345125. Epub 2012 Nov 20. PubMed PMID:23182917.

Christensen JH, Jensen PV, Kristensen IB, Abildgaard N, Lodahl M, Rasmussen T. Characterization of potential CD138 negative myeloma "stem cells". Haematologica. 2012 Jun;97(6):e18-20. doi:10.3324/haematol.2011.043125. PubMed PMID: 22665530;
PubMed Central PMCID: PMC3366666.

Haidl F, Plesner T, Lund T. Treatment with bortezomib in multiple myeloma is associated with only a transient and brief increase of bone specific alkaline phosphatase. Leuk Res. 2012 Oct;36(10):1296-9. doi:
10.1016/j.leukres.2012.06.007. Epub 2012 Jun 29. PubMed PMID: 22748823.

Hansen CT, Münster AM, Nielsen L, Pedersen P, Abildgaard N. Clinical and
preclinical validation of the serum free light chain assay: identification of the critical difference for optimized clinical use. Eur J Haematol. 2012
Dec;89(6):458-68. doi: 10.1111/ejh.12013. Epub 2012 Oct 16. PubMed PMID:22998393.

Hjorth M, Hjertner Ø, Knudsen LM, Gulbrandsen N, Holmberg E, Pedersen PT, Andersen NF, Andréasson B, Billström R, Carlson K, Carlsson MS, Flogegård M, Forsberg K, Gimsing P, Karlsson T, Linder O, Nahi H, Othzén A, Swedin A; Nordic Myeloma Study Group (NMSG). Thalidomide and dexamethasone vs. bortezomib and dexamethasone for melphalan refractory myeloma: a randomized study. Eur J Haematol. 2012 Jun;88(6):485-96. doi: 10.1111/j.1600-0609.2012.01775.x. Epub 2012 Mar 30. PubMed PMID: 22404182; PubMed Central PMCID: PMC3492844.

Kloster MB, Bilgrau AE, Rodrigo-Domingo M, Bergkvist KS, Schmitz A, Sønderkær M, Bødker JS, Falgreen S, Nyegaard M, Johnsen HE, Nielsen KL, Dybkaer K, Bøgsted M. A model system for assessing and comparing the ability of exon microarray and tag sequencing to detect genes specific for malignant B-cells. BMC Genomics. 2012 Nov 5;13:596. doi: 10.1186/1471-2164-13-596. PubMed PMID: 23127183; PubMed Central PMCID: PMC3505742.

Kolmos EB, Moth Henriksen M, Abildgaard N, Sindrup SH. [A syndrome of chronic ataxic polyneuropathy, ophtalmoplegia, IgM paraprotein, cold agglutinins and anti-disialosyl antibodies can cause diplopia in patients with chronic sensory polyneuropathy]. Ugeskr Laeger. 2012 Oct 22;174(43):2635-6. Danish. PubMed PMID:23095653.

Kristensen IB, Haaber J, Lyng MB, Knudsen LM, Rasmussen T, Ditzel HJ,
Abildgaard N. Myeloma plasma cell expression of osteoblast regulatory genes:overexpression of SFRP3 correlates with clinical bone involvement at diagnosis. Leuk Lymphoma. 2013 Feb;54(2):425-7. doi: 10.3109/10428194.2012.708027. Epub 2012
Aug 7. PubMed PMID: 22742577.

Kumar SK, Lee JH, Lahuerta JJ, Morgan G, Richardson PG, Crowley J, Haessler J, Feather J, Hoering A, Moreau P, LeLeu X, Hulin C, Klein SK, Sonneveld P, Siegel D, Bladé J, Goldschmidt H, Jagannath S, Miguel JS, Orlowski R, Palumbo A, Sezer O, Rajkumar SV, Durie BG; International Myeloma Working Group. Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group study. Leukemia. 2012 Jan;26(1):149-57. doi: 10.1038/leu.2011.196. Epub 2011 Jul 29. Erratum in: Leukemia. 2012 May;26(5):1153. Nari, Hareth [corrected to Nahi, Hareth]. PubMed PMID: 21799510.

Martino A, Campa D, Jamroziak K, Reis RM, Sainz J, Buda G, García-Sanz R,
Lesueur F, Marques H, Moreno V, Jurado M, Ríos R, Szemraj-Rogucka Z, Szemraj J, Tjønneland A, Overvad K, Vangsted AJ, Vogel U, Mikala G, Kádár K, Szombath G, Varkonyi J, Orciuolo E, Dumontet C, Gemignani F, Rossi AM, Landi S, Petrini M, Houlston RS, Hemminki K, Canzian F. Impact of polymorphic variation at 7p15.3, 3p22.1 and 2p23.3 loci on risk of multiple myeloma. Br J Haematol. 2012 Sep;158(6):805-9. doi: 10.1111/j.1365-2141.2012.09244.x. Epub 2012 Jul 24. PubMed PMID: 22823248.

Morgan G, Johnsen HE, Goldschmidt H, Palumbo A, Cavo M, Sonneveld P, Miguel JS, Chim CS, Browne P, Einsele H, Waage A, Turesson I, Spencer A, Hajek R, Ludwig H, Hemminki K, Houlston R. MyelomA Genetics International Consortium. Leuk Lymphoma. 2012 May;53(5):796-800. doi: 10.3109/10428194.2011.639881. Epub 2012 Jan 3. Review. PubMed PMID: 22080755.

Moth Henriksen M, Kolmos EB, Abildgaard N, Schrøder HD, Sindrup S.
[Polyneuropathy associated with monoclonal gammopathy of undetermined
significance]. Ugeskr Laeger. 2012 Oct 22;174(43):2630-4. Review. Danish. PubMed PMID: 23095652.

Palumbo A, Waage A, Hulin C, Beksac M, Zweegman S, Gay F, Gimsing P, Leleu X, Wijermans P, Sucak G, Pezzatti S, Juliusson G, Pégourié B, Schaafsma M, Galli M, Turesson I, Kolb B, van der Holt B, Baldi I, Rolke J, Ciccone G, Wetterwald M, Lokhorst H, Boccadoro M, Rodon P, Sonneveld P. Safety of thalidomide in newly diagnosed elderly myeloma patients: a meta-analysis of data from individual patients in six randomized trials. Haematologica. 2013 Jan;98(1):87-94. doi: 10.3324/haematol.2012.067058. Epub 2012 Aug 8. PubMed PMID: 22875621; PubMed Central PMCID: PMC3533664.

Palumbo A, Hajek R, Delforge M, Kropff M, Petrucci MT, Catalano J, Gisslinger H, Wiktor-Jędrzejczak W, Zodelava M, Weisel K, Cascavilla N, Iosava G, Cavo M, Kloczko J, Bladé J, Beksac M, Spicka I, Plesner T, Radke J, Langer C, Ben Yehuda D, Corso A, Herbein L, Yu Z, Mei J, Jacques C, Dimopoulos MA; MM-015 Investigators. Continuous lenalidomide treatment for newly diagnosed multiple myeloma. N Engl J Med. 2012 May 10;366(19):1759-69. doi: 10.1056/NEJMoa1112704. Erratum in: N Engl J Med. 2012 Jul 19;367(3):285. PubMed PMID: 22571200.

Popat R, Plesner T, Davies F, Cook G, Cook M, Elliott P, Jacobson E,
Gumbleton T, Oakervee H, Cavenagh J. A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma. Br J Haematol. 2013 Mar;160(5):714-7. doi: 10.1111/bjh.12154. Epub 2012 Dec 4. PubMed
PMID: 23205612.

Ross FM, Avet-Loiseau H, Ameye G, Gutiérrez NC, Liebisch P, O'Connor S, Dalva K, Fabris S, Testi AM, Jarosova M, Hodkinson C, Collin A, Kerndrup G, Kuglik P, Ladon D, Bernasconi P, Maes B, Zemanova Z, Michalova K, Michau L, Neben K, Hermansen NE, Rack K, Rocci A, Protheroe R, Chiecchio L, Poirel HA, Sonneveld P, Nyegaard M, Johnsen HE; European Myeloma Network. Report from the European Myeloma Network on interphase FISH in multiple myeloma and related disorders. Haematologica. 2012 Aug;97(8):1272-7. Epub 2012 Feb 27. PubMed PMID: 22371180; PubMed Central PMCID: PMC3409827.

Valent P, Bonnet D, De Maria R, Lapidot T, Copland M, Melo JV, Chomienne C, Ishikawa F, Schuringa JJ, Stassi G, Huntly B, Herrmann H, Soulier J, Roesch A, Schuurhuis GJ, Wöhrer S, Arock M, Zuber J, Cerny-Reiterer S, Johnsen HE, Andreeff M, Eaves C. Cancer stem cell definitions and terminology: the devil is in the details. Nat Rev Cancer. 2012 Nov;12(11):767-75. doi: 10.1038/nrc3368. Epub 2012 Oct 11. PubMed PMID: 23051844.

Vangsted A, Klausen TW, Vogel U. Genetic variations in multiple myeloma I: effect on risk of multiple myeloma. Eur J Haematol. 2012 Jan;88(1):8-30. doi: 10.1111/j.1600-0609.2011.01700.x. Epub 2011 Nov 17. Review. PubMed PMID: 21883480.

Vangsted A, Klausen TW, Vogel U. Genetic variations in multiple myeloma II: association with effect of treatment. Eur J Haematol. 2012 Feb;88(2):93-117. doi: 10.1111/j.1600-0609.2011.01696.x. Epub 2011 Nov 16. Review. PubMed PMID: 21883476.

Vangsted AJ, Nielsen KR, Klausen TW, Haukaas E, Tjønneland A, Vogel U. A
functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma. Br J Haematol. 2012 Aug;158(4):515-8. doi: 10.1111/j.1365-2141.2012.09141.x. Epub 2012 Apr 28. PubMed PMID: 22540426.

Årsrapport 2011 for Dansk Myelomatose Studie Gruppe og den landsdækkende myelomatose database. 2012. www.myeloma.dk

2011

Abildgaard N. Subkutan Velcade behandling ved myelomatose. BestPractice Hæmatologi, Vol. 1, 2011, s. 16-18.

Andersen NF, Vogel U, Klausen TW, Gimsing P, Gregersen H, Abildgaard N, Vangsted AJ. Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalodomide in multiple myeloma. Int J Cancer, 2011 [Epub ahead of print].

Boegsted M, Holst JM, Fogd K, Falgreen S, Sørensen S, Schmitz A, Bukh A, Johnsen HE, Nyegaard M, Dybkaer K. Generation of a predictive melphalan resistance index by drug screen of B-cell cancer cell lines. PLoS One, 2011; 29: e19322.

Cavo M, Rajkumar SV, Palumbo A, Moreau P, Orlowski R, Bladé J, Sezer O, Ludwig H, Dimopoulos MA, Attal M, Sonneveld P, Boccadoro M, Anderson KC, Richardson PG, Bensinger W, Johnsen HE, Kroeger N, Gahrton G, Bergsagel PL, Vesole DH, Einsele H, Jagannath S, Niesvizky R, Durie BG, San Miguel J, Lonial S; International Myeloma Working Group. International Myeloma Working Group consensus approach to the treatment of multiple myeloma patients who are candidates for autologous stem cell transplantation. Blood, 2011; 117: 6063-73.

Fayers PM, Palumbo A, Hulin C, Waage A, Wijermans P, Beksaç M, Bringhen S, Mary JY, Gimsing P, Termorshuizen F, Haznedar R, Caravita T, Moreau P, Turesson I, Musto P, Benboubker L, Schaafsma M, Sonneveld P, Facon T; Nordic Myeloma Study Group; Italian Multiple Myeloma Network; Turkish Myeloma Study Group; Hemato-Oncologie voor Volwassenen Nederland; Intergroupe Francophone du Myélome; European Myeloma Network. Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trials. Blood, 2011; 118: 1239-47.

Larsen LH, Lund T, Vilholm OJ, Plesner T. Anti-myelin associated glycoprotein neuropathy responding to lenalidomide. Leuk Res, 2011; 35: e198-9.

Ludwig H, Beksaç M, Bladé J, Cavenagh J, Cavo M, Delforge M, Dimopoulos M, Drach J, Einsele H, Facon T, Goldschmidt H, Harousseau JL, Hess U, Kropff M, Leal da Costa F, Louw V, Magen-Nativ H, Mendeleeva L, Nahi H, Plesner T, San-Miguel J, Sonneveld P, Udvardy M, Sondergeld P, Palumbo A. Multiple myeloma treatment strategies with novel agents in 2011: a European perspective. Oncologist, 2011; 16: 388-403.

Mellstedt H, Gimsing P, Waage A. Treatment of myeloma when high dose therapy is not possible. New drugs alternatives for elderly patients. Lakartidningen. 2011 Oct 19-25; 108(42): 2090-4.

Palumbo A, Bringhen S, Ludwig H, Dimopoulos M, Bladé J, Mateos MV, Rosiñol L, Boccadoro M, Cavo M, Lokhorst H, Zweegman S, Terpos E, Davies F, Driessen C, Gimsing P, Gramatzki M, Hàjek R, Johnsen HE, Leal da Costa F, Sezer O, Spencer A, Beksaç M, Morgan G, Einsele H, San Miguel JF, Sonneveld P. Personalized therapy in multiple myeloma according to patient age and vulnerability: a report of the European Myeloma Network (EMN). Blood, 2011; 118: 4519-29.

Paiva B, Pérez-Andrés M, Vídirales MB, Almeida J, de las Heras N, Mateos MV, López-Corral L, Gutiérrez NC, Blanco J, Oriol A, Hernández MT, de Arriba F, de Coca AG, Terol MJ, de la Rubia J, González Y, Martín A, Sureda A, Schmidt-Hieber M, Schmitz A, Johnsen HE, Lahuerta JJ, Bladé J, San-Miguel JF, Orfao A; GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas); Myeloma Stem Cell Network (MSCNET). Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution in MGUS vs myeloma. Leukemia, 2011; 25: 697-706.

Van de Donk NW, Lokhorst HM, Dimopoulos M, Cavo M, Morgan G, Einsele H, Kropff M, Schey S, Avet-Loiseau H, Ludwig H, Goldschmidt H, Sonneveld P, Johnsen HE, Bladé J, San-Miguel JF, Palumbo A. Treatment of relapsed and refractory multiple myeloma in the era of novel agents. Cancer Treat Rev, 2011; 37: 266-81.

Vangsted AJ, Klausen TW, Abildgaard N, Andersen NF, Gimsing P, Gregersen H, Nexø BA, Vogel U. Single nucleotide polymorphisms in the promoter region of the IL1B gene influence outcome in multiple myeloma patients treated with high-dose chemotherapy independently of relapse treatment with thalidomide and bortezomib. Ann Hematol, 2011; 90:1173-81.

Vangsted AJ, Klausen TW, Gimsing P, Abildgaard N, Andersen NF, Gregersen H, Nexø BA, Vogel U. The importance of a sub-region on chromosome 19q13.3 for prognosis of multiple myeloma patients after high-dose treatment and stem cell support: a linkage disequilibrium mapping in RAI and CD3EAP. Ann Hematol, 2011; 90: 675-84.

2010

Andersen TL, Søe K, Sondergaard TE, Plesner T, Delaisse JM. Myeloma cell-induced disruption of bone remodelling compartments leads to osteolytic lesions and generation of osteoclast-myeloma hybrid cells. Br J Haematol. 2010 Feb;148(4):551-61. Epub 2009 Nov 16.

Brimnes MK, Vangsted AJ, Knudsen LM, Gimsing P, Gang AO, Johnsen HE, Svane IM. Increased level of both CD4+FOXP3+ regulatory T cells and CD14+HLA-DR⁻/low myeloid-derived suppressor cells and decreased level of dendritic cells in patients with multiple myeloma. Scand J Immunol. 2010 Dec;72(6):540-7.

Engelhardt M, Udi J, Kleber M, Spencer A, Rocci A, Knop S, Bruno B, Bringhen S, Pérez-Simón JA, Zweegman S, Driessen C, Patriarca F, Gramatzki M, Terpos E, Sezer O, Kropff M, Straka C, Johnsen HE, Waage A, Boegsted M, Lokhorst H, Hájek R, Morgan G, Boccadoro M, Ludwig H, Cavo M, Polliack A, Sonneveld P, Einsele H, Palumbo A. European Myeloma Network: the 3rd Trialist Forum Consensus Statement from the European experts meeting on multiple myeloma. Leuk Lymphoma. 2010; 51:2006-11. Epub 2010 Aug 31.

Gang AO, Arpi M, Uffe J.O. Gang, Vangsted AJ. Early infections in patients undergoing high-dose treatment with stem cell support: a comparison of patients with non-Hodgkin lymphoma and multiple myeloma. Haematology, 2010; 15: 222-29.

Gimsing P, Carlson K, Turesson I, Fayers P, Waage A, Vangsted A, Mylin A, Gluud C, Juliusson G, Gregersen H, Hjorth-Hansen H, Nesthus I, Dahl IM, Westin J, Nielsen Jl, Knudsen LM, Ahlberg L, Hjorth M, Abildgaard N, Andersen NF, Linder O, Wisløff F. Effect of pamidronate 30 mg versus 90 mg on physical function in patients with newly diagnosed multiple myeloma (Nordic Myeloma Study Group): a double blind, randomised controlled trial. Lancet Oncol. 2010; 11: 973-82.

Gregersen H, Nørgaard M, Severinsen MT, Engebjerg MC, Jensen P, Sørensen HT. Monoclonal gammopathy of undetermined significance and risk of venous thromboembolism. Eur J Haematol. 2011; 86:129-34. (Epub 2010 Dec 22).

Gregersen H, Sørensen HT, Engebjerg MC, Jensen P, Severinsen MT, Nørgaard M. Survival of cancer patients with prior monoclonal gammopathy of undetermined significance. Eur J Intern Med. 2010; 21: 564-8 (Epub 2010 Sep 19).

Hansen CT, Nielsen L, Münster AM, Abildgaard N. Determination of light chains in serum. Ugeskr Laeger. 2010; 172: 2302-2305.

Johansen JS, Bojesen SE, Tybjaerg-Hansen A, Mylin AK, Price PA, Nordestgaard BG. Plasma YKL-40 and total and disease-specific mortality in the general population. Clin Chem. 2010; 56:1580-91. (Epub 2010 Aug 26).

Johnsen HE, Klausen TW, Boegsted M, Lenhoff S, Gimsing P, Christiansen I, Gedde-Dahl T, Lindås R, Mellqvist UH; Nordic Myeloma Study Group. Improved survival for multiple myeloma in denmark based on autologous stem cell transplantation and novel drug therapy in collaborative trials: analysis of accrual, prognostic variables, selection bias, and clinical behavior on survival in more than 1200 patients in trials of the nordic myeloma study group. Clin Lymphoma Myeloma Leuk. 2010; 10: 290-6.

Johnsen HE, Bøgsted M, Klausen TW, Gimsing P, Schmitz A, Kjaersgaard E, Damgaard T, Voss P, Knudsen LM, Mylin AK, Nielsen JL, Björkstrand B, Gruber A, Lenhoff S, Remes K, Dahl IM, Fogd K, Dybkaer K; Nordic Myeloma Study (NMSG); Myeloma Stem Cell Network (MSCNET). Multiparametric flow cytometry profiling of neoplastic plasma cells in multiple myeloma. Cytometry B Clin Cytom. 2010; 78: 338-47.

Kupisiewicz K, Boissy P, Abdallah BM, Hansen FD, Erben RG, Savouret JF, Søe K, Andersen TL, Plesner T, Delaisse JM. Potential of resveratrol analogues as antagonists of osteoclasts and promoters of osteoblasts. Calcif Tissue Int. 2010; 87: 437-49. (Epub 2010 Sep 15).

Ludwig H, Beksac M, Bladé J, Boccadoro M, Cavenagh J, Cavo M, Dimopoulos M, Drach J, Einsele H, Facon T, Goldschmidt H, Harousseau JL, Hess U, Ketterer N, Kropff M, Mendeleeva L, Morgan G, Palumbo A, Plesner T, San Miguel J, Shpilberg O, Sondergeld P, Sonneveld P, Zweegman S. Current multiple myeloma treatment strategies with novel agents: a European perspective. Oncologist. 2010; 15: 6-25. (Epub 2010 Jan 19). Review.

Lund T, Abildgaard N, Andersen TL, Delaisse JM, Plesner T. Multiple myeloma: changes in serum C-terminal telopeptide of collagen type I and bone-specific alkaline phosphatase can be used in daily practice to detect imminent osteolysis. European Journal of Haematology, 2010; 84: 412-20.

Lund T, Søe K, Abildgaard N, Garnero P, Pedersen PT, Ormstrup T, Delaissé JM, Plesner T. First-line treatment with bortezomib rapidly stimulates both osteoblast activity and bone matrix deposition in patients with multiple myeloma, and stimulates osteoblast proliferation and differentiation in vitro. European Journal of Haematology, 2010; 85: 290-9.

Lund T, Abildgaard N, Delaisse JM, Plesner T. Effect of withdrawal of zoledronic acid treatment on bone remodelling markers in multiple myeloma. British Journal of Haematology, 2010; 151: 92-3.

Perez-Andres M, Paiva B, Nieto WG, Caraux A, Schmitz A, Almeida J, Vogt RF Jr, Marti GE, Rawstron AC, Van Zelm MC, Van Dongen JJ, Johnsen HE, Klein B, Orfao A; Primary Health Care Group of Salamanca for the Study of MBL. Human peripheral blood B-cell compartments: a crossroad in B-cell traffic. Cytometry B Clin Cytom. 2010; 78 Suppl 1: S47-60. Review.

Rasmussen T, Haaber J, Dahl IM, Knudsen LM, Kerndrup GB, Lodahl M, Johnsen HE, Kuehl M. Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma. Haematologica. 2010; 95: 1730-7.Retningslinje for diagnostik og behandling af myelomatose. DMSG, 2010, www.myeloma.dk

Terpos E, Dimopoulos MA, Sezer O, Roodman D, Abildgaard N, Vescio R, Tosi P, Garcia-Sanz R, Davies F, Chanan-Khan A, Palumbo A, Sonneveld P, Drake MT, Harousseau JL, Anderson KC, Durie BG. The use of biochemical markers of bone remodelling in multiple myeloma: a report of the international Myeloma Working Group. Leukaemia. 2010; 24: 1700-1712.

Urup T, Madsen G, Hallager S, Schmitz A, Fogd K, Bøgsted M, Nyegaard M, Sørensen KD, Johnsen HE. Cancer stem cells in the haematopoietic system. Ugeskr Laeger. 2010; 172: 2597-600.

Van de Donk NW, Lokhorst HM, Dimopoulos M, Cavo M, Morgan G, Einsele H, Kropff M, Schey S, Avet-Loiseau H, Ludwig H, Goldschmidt H, Sonneveld P, Johnsen HE, Bladé J, San-Miguel JF, Palumbo A. Treatment of relapsed and refractory multiple myeloma in the era of novel agents. Cancer Treat Rev. 2011; 37: 266-83. (Epub 2010 Sep 21). Review.

Vangsted AJ, Søeby K, Klausen TW, Abildgaard N, Andersen NF, Gimsing P, Gregersen H, Vogel UB, Werge T, Rasmussen HB. No influence of genetic polymorphisms CYP2C19 and CYP2D6 on the efficacy of cyclophosphamid,e thalidomide, and bortezomib in patients with Multiple Myeloma. BMC Cancer. 2010; 10: 404.

Vangsted AJ, Klausen TW, Andersen NF, Abildgaard N, Gang AO, Gregersen H, Vogel U, Gimsing P. Improved survival of multiple myeloma patients with late relapse after high-dose treatment and stem cell support, a population-based study of 348 patients in Denmark in 1994-2004. Eur J Haematol. 2010; 85: 209-216.

Vangsted AJ, Klausen TW, Gimsing P, Abildgaard N, Andersen NF, Gregersen H, Nexø, BA, Vogel U. The importance of a sub-region on chromosome 19q13.3 for prognosis of multiple myeloma patients after high-dose treatment and stem cells support: A linkage disequilibrium mapping in RAI and CD3EAP. Ann. Hematol. (Epub 2010 Nov 3).

Waage A, Gimsing P, Fayers P, Abildgaard N, Ahlberg L, Björkstrand B, Carlson K, Dahl IM, Forsberg K, Gulbrandsen N, Haukas E, Hjertner O, Hjorth M, Karlsson T, Knudsen L, Nielsen JL, Linder O, Mellqvist UH, Nesthus I, Rolke J, Strandberg M, Sorbo JH, Wisloff F, Juliusson G, Turesson I. Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma. Blood. 2010; 116: 1405-1412.

2009

Bird J, Behrens J, Westin J, Turesson I, Drayson M, Beetham R, D'Sa S, Soutar R,Waage A, Gulbrandsen N, Gregersen H, Low E. UK Myeloma Forum (UKMF) and Nordic Myeloma Study Group (NMSG): guidelines for the investigation of newly detected M-proteins and the management of monoclonal gammopathy of undetermined significance (MGUS). British Journal of Haematology, 2009; 147: 22-42.

Björkstrand, B, Klausen TW, Remes K, Gruber A, Knudsen LM, Bergmann OJ, Lenhoff S, Johnsen HE. Double versus single high dose melphalan 200 mg/m2 and autologous stem-cell transplantation for multiple myeloma: A region based study in 484 patients from the Nordic Area. Haematology Review/Reports, Vol 1, No 2; p 62-64; 2009.
Damgaard,T., Knudsen,L.M., Dahl,I.M., Gimsing,P., Lodahl,M., & Rasmussen,T. Regulation of the CD56 promoter and its association with proliferation, anti-apoptosis and clinical factors in multiple myeloma. Leuk Lymphoma, 2009; 50: 236-246.

Gimsing,P.  Belinostat: a new broad acting antineoplastic histone deacetylase inhibitor. Expert Opinion on Investigational Drugs, 2009; 18: 501-508.

Hesse,B. & Gimsing,P. Can amyloidosis scintigraphy be useful?. Ugeskr.Laeger, 2009; 171: 1835.

Madsen,L.G., Gimsing,P., & Schiodt,F.V. Primary (AL) amyloidosis with gastrointestinal involvement. Scandinavian Journal of Gastroenterology, 2009; 44: 708-711.

Mylin,A.K., Andersen,N.F., Johansen,J.S., Abildgaard,N., Heickendorff,L., Standal,T., Gimsing,P., & Knudsen,L.M. (2009) Serum YKL-40 and bone marrow angiogenesis in multiple myeloma. International Journal of Cancer, 2009; 124: 1492-1494.

Vangsted,A.J., Klausen,T.W., Gimsing,P., Andersen,N.F., Abildgaard,N., Gregersen,H., & Vogel,U. A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support. Haematologica, 2009; 94: 1274-1281.

Vangsted,A.J., Klausen,T.W., Ruminski,W., Gimsing,P., Andersen,N.F., Gang,A.O., Abildgaard,N., Knudsen,L.M., Nielsen,J.L., Gregersen,H., & Vogel,U. The polymorphism IL-1beta T-31C is associated with a longer overall survival in patients with multiple myeloma undergoing auto-SCT. Bone Marrow Transplantation, 2009; 43: 539-545.

Lund T, Gregersen H, Vangsted A, Marker P, Abildgaard N. Bisphosphonate-associated osteonecrosis of the jaw in patients with multiple myeloma. Ugeskr Laeger, 2009;  5: 171(1-2):50-2.

Sondergaard TE, Pedersen PT, Andersen TL, Søe K, Lund T, Ostergaard B, Garnero P, Delaisse JM, Plesner T. A phase II clinical trial does not show that high dose simvastatin has beneficial effect on markers of bone turnover in multiple myeloma. Journal of Hematology & Oncology, 2009; 27(1):17-22.

Andersen TL, Sondergaard TE, Skorzynska KE, et al.  A Physical Mechanism for Coupling Bone Resorption and Formation in Adult Human Bone. American Journal of Pathology, 2009; 174 (1): 239-247.

Johnsen HE, Kjeldsen MK, Urup T, Fogd K, Pilgaard L, Boegsted M, Nyegaard M, Christiansen I, Bukh A, Dybkaer K. Cancer stem cells and the cellular hierarchy in haematological malignancies. European Journal of Cancer, 2009; 45 (1)1:194-201.

Johnsen HE, Knudsen LM, Mylin AK, Gimsing P, Gregersen H, Abildgaard N, Andersen NF, Plesner T, Vangsted AJ, Mourits-Andersen T, on behalf of the Nordic Myeloma Study Group: Up-front fludarabine impairs stem cell harvest in multiple myeloma : report from an interim analysis of the NMSG 13/03 randomized placebo controlled phase II trial.  Haematology, 2009; 1 (1): 9-13.

Björkstrand B, Klausen TW, Remes K, Gruber A, Knudsen LM, Bergmann OJ, Lenhoff S, Johnsen HE. Double versus single high dose melphalan 200 mg/m2 and autologous stem-cell transplantation for multiple myeloma: A region based study in 484 patients from the Nordic Area. Haematology Review/Reports, 2009; 1 (2): 62-64.

Mylin AK, Rasmussen T, Lodahl M, Dahl IM, Knudsen LM. Upregulated MCL1 mRNA expression in multiple myeloma lacks association with survival. British Journal of Haematology, 2009; 144 (6): 961-3.

2008

Boissy P, Andersen TL, Lund T, Kupisiewicz K, Plesner T, Delaissé JM. Pulse
treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions. Leukemia Research, 2008; 32: 1661-68.

Gimsing P, Hansen H, Knudsen LM, Knoblauch P, Christensen IJ, Ooi CE, Jensen PB. A phase I clinical trial of the histone deacetylase inhibitor belinostat (PXD101) in patients with advanced haematological neoplasia. European Journal of Haematology, 2008; 81: 170-76.

Grønbæk K, Ralfkjær U, Dahl C, Hother C, Burns JS, Kassem M, Worm J, Ralfkjær EM, Knudsen LM, Hokland P, Guldberg P. Frequent hypermetylation of DBC1 in malignant lymphoproliferative neoplasms. Modern Pathology, 2008; 21: 632-8.

Haaber J, Abildgaard N, Knudsen LM, Dahl IM, Lodahl M, Thomassen M, Kerndrup GB, Rasmussen T. Myeloma cell expression of 10 candidate genes for osteolytic bone disease. Only overexpression of DKK1 correlates with clinical bone involvement at diagnosis. British Journal of  Haematology, 2008: 140; 25-35.

Hasselbalch H, Birgens H, Dufva IH, Dalseg AM, de Nully Brown P, Nielsen MK, Vangsted A. Nye medicinske behandlingsprincipper inden for hæmatologien.  Ugeskrift for Læger 2008; 170, 24:2115-2119.

Hermansen NE, Gimsing P. Patient heterogeneity in phase II studies of refractory disease in Multiple  myeloma the 'spell' of the time to first relapse. British Journal of Haematology, 2008 ; 140:115-16.

Mylin AK, Abildgaard N, Johansen JS, Andersen NF, Heickendorff L, Standal T, Gimsing P, Knudsen LM. High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients. European Journal of Haematology. 2008; 80: 310-7.

Rawstron AC, Orfao A, Beksac M, Bezdickova L, Brooimans RA, Bumbea H, Dalva K, Fuhler, Gratama J, Hose D, Kovarova L, Lioznov M, Mateo G, Morilla R, Mylin AK, Omedé P, Pellat-Deceunynck C, Perez Andres M, Petrucci M, Ruggeri M, Rymkiewicz G,Schmitz A, Schreder M, Seynaeve C, Spacek M, de Tute, Van Valckenborgh E, Weston-Bell N, Owen RG, San Miguel JF, Sonneveld P, Johnsen HE; European Myeloma Network. Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders. Haematologica, 2008; 93: 431-8.

2007

Andersen, TL; Boissy, P; Sondergaard, TE; Kupisiewicz, K; Plesner, T; Rasmussen, T; Haaber, J; Kølvraa, S; Delaissé, JM. Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: a new type of cancer-host partnership? Journal of  Pathology, 2007; 211: 10-7.

Brandslund, I; Poulsen, JH; Petersen, PH; Pedersen, ML; Gerdes, LU; Plum, I. Ens referenceintervaller og harmoniserede resultater inden for klinisk biokemi i de nordiske lande - der er lys forude. Ugeskrift For Læger, 2007; 169: 1216-1218.

Christensen, JH; Abildgaard, N; Plesner, T; Nibe, A; Nielsen, O; Sørensen, AG; Kerndrup, GB. Leukemia/Lymphoma Study Group, Region of Southern Denmark. Interphase fluorescence in situ hybridization in multiple myeloma and monoclonal gammopathy of undetermined significance without and with positive plasma cell identification: analysis of 192 cases from the Region of Southern Denmark. Cancer Genetics Cytogenetics, 2007; 174: 89-99.

D´Sa, S; Abildgaard, N; Tighe, J; Shaw, P & Hall-Craggs, M. Guidelines for the use of imaging in the management of myeloma. British Journal of Haematology, 2007;137:49-63.

Rendtlew, J; Danielsen, JM; Knudsen, LM; Dahl, IM; Lodahl, M; Rasmussen, T. Dysregulation of CD47 and the ligands thrombospondin 1 and 2 in multiple myeloma. British Journal of Haematology, 2007 ; 138: 756-60.

Standal, T;  Abildgaard, N; UM. Fagerli; B. Stordal; O. Hjertner; M. Borset & A. Sundan. HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma. Blood, 2007; 109: 3024-30.

Svane, IM; Nikolajsen, K; Johnsen, HE. Antigen-specific T-cell immunity in multiple myeloma patients is restored following high-dose therapy: implications for timing of vaccination. Scandinavian Journal of Immunology, 2007; 66: 465-75.

2006

Bonhorst, J; Knudsen, LM; Rasmusssen, T; Moen, SH; Fløttum, M; Sundan, A; Espevik, T, Proliferation and survival in multiple myeloma cells due to Toll-like receptor expression.  Leukemia 2006; 20: 1138-44.

Chabanova, E; Johnsen, HE; Knudsen, LM; Larsen, L; Løgager, V; Yingru, S. Magnetic resonance investigation of bone marrow following priming and stem cell mobilization. Magnetic Resonance in Medicine 2006; 24: 1364-70.

Gregersen, H; Jensen, P; Gislum, M; Jørgensen, B; Sørensen, HT; Nørgaard, M. Fracture risk in patients with monoclonal gammopathy of undetermined significance. British Journal of Haematology, 2006: 135; 62-67.

Lenhoff, S; Hjorth, M; Westin, J; Brinch, L: Bäckström, B: Carlson, K; Christiansen, I; Dahl, IM; Gimsing, P; Hammerström, J; Johnsen, HE; Juliusson, G; Linder, O; Mellqvist, UH; Nesthus, I; Nielsen, JL; Tangen, JM; Turesson, I; for the Nordic Myeloma Study Group. The impact of age on survival after intensive therapy for multiple myeloma: a population-based study by the Nordic Myeloma Study Group. British Journal of Haematology, 2006; 133: 389-96.

Lenhoff, S; Hjorth, M; Turesson, I; Westin, J; Gimsing, P; Wislöff, F; Ahlberg, L; Carlson, K; Christiansen, I; Dahl, IM; Forsberg, K; Brinch, L; Hammerström, J; Johnsen, HE; Knudsen, LM; Linder, O; Mellqvist, UH; Nesthus, I; Nielsen, JL; Nordic Myeloma Study Group. Intensive therapy for multiple myeloma in patients younger than 60 years. Long-term results focusing on the effect of the degree of response on survival and relapse pattern after transplantation. Haematologica, 2006; 91: 1228-33.

Mylin, AK; Rasmussen, T; Johansen, TS; Knudsen, LM; Nørgaard, PH; Lenhoff, S; Dahl, IM; and Johnsen; HE for the Nordic Myeloma Study Group. Serum YKL-40 concentration in newly diagnosed multiple myeloma patients and YKL-40 expression in malignant plasma cells. European Journal of Haematology, 2006; 77: 416-24.

Roer, O; Hammerstrøm, J; Lenhoff, S; Mylin, AK; Knudsen, LM; Rasmussen, T; and Johnsen, HE, for the Nordic Myeloma Study Group. Quality assessment of autografting by probability evaluation: model estimation by clinical end-points in newly diagnosed multiple myeloma patients. Cytotherapy, 2006; 8: 79-88.

Smith, A; Wisloff, F; Samson, D et al. Guidelines on the diagnosis and management of multiple myeloma 2005. British Journal of Haematology, 2006, 132: 410-451.

Vangsted, A; Gimsing, P; Clausen, T.W; Andersen Nexø, A; Wallin, H; Andersen, P; Hokland, P; Lillevang, S.T. and Vogel, U. Polymorphism in the genes CD3EAP, ERCC2 and XRCC3 influences treatment outcome in Multiple Myeloma undergoing autologous bone marrow transplantation. International Journal of Cancer, 2006; 120: 1036-1045.

2005

Andersen, NF.; Standal, T;  Nielsen, JL; Heickendorff, L; Sørensen, FB; & Abildgaard, N. Syndecan-1 and angiogenic cytokines in multiple myeloma: correlation with bone marrow angiogenesis and survival. British Journal of Haematology, 2005; 128: 210-217.

Boissy, P; Andersen, TL; Abdallah, BM; Kassem, M; Plesner, T; Delaissé, JM. Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation. Cancer Res, 2005; 65: 9943-52.

Carlson, K; Hjorth, M; Knudsen, LM, for the Nordic Myeloma Study Group. Toxicity in standard melphalan-prednisone therapy among myeloma patients with renal failure – a retrospective analysis and recommendations for dose adjustment. British Journal of Haematology, 2005; 128: 631-5.

Hudlebusch HR, Theilgaard-Monch K, Lodahl M, Johnsen HE, Rasmussen T. Identification of ID-1 as a potential target gene of MMSET in multiple myeloma. British Journal of Haematology. 130: 700-8. 2005.

Knudsen, LM; Nielsen, B; Gimsing, P; Geisler, C, Autologous stem cell transplantation in multiple myeloma: Outcome in patients with renal failure. European Journal of  Haematology, 2005; 74: 1-7.